The Architectural Shift in Depression Why Brain Network Topology Is...

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2026-05-06 08:59:58 -

The Architectural Shift in Depression Why Brain Network Topology Is Redefining CNS Strategy

By Denis Katz, MD, MHAFounder, Salience Clinical Beyond the Chemistry Paradigm For decades, major depressive disorder (MDD) has been framed as a disorder of neurotransmitters primarily serotonin, norepinephrine, and dopamine. This model enabled meaningful therapeutic progress, but its limits are increasingly clear. A large proportion of patients do not achieve sustained remission. Treatment...

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